Health officials in England have identified a newly evolved mpox variant after a person who recently travelled to Asia tested positive for the virus. Genome analysis revealed that the strain is a recombinant form, containing genetic material from both major mpox clades currently circulating: the more severe clade 1 and the less virulent clade 2, which caused the global outbreak in 2022.
The UK Health Security Agency stated that it is still evaluating the significance of the mutation, noting that such recombination is not unexpected while both variants exist in the population. Experts say continuous genomic monitoring remains crucial as viruses naturally evolve.
Mpox – formerly monkeypox – spreads through close physical contact with infected blisters, scabs or contaminated materials such as clothing and bedding. It can also be transmitted through coughs, sneezes or contact with infected animals like rodents. Symptoms may take up to three weeks to appear and typically include fever, headache, muscle pain and exhaustion, followed by a rash.
While most mpox infections are mild, officials urged eligible individuals – particularly those with multiple sexual partners or who visit sex-on-premises venues – to get vaccinated. A WHO emergency response ended earlier this year after outbreaks affecting multiple countries, though mpox continues to circulate globally.
Scientists say the key now is to monitor whether the new recombinant behaves differently in terms of transmission or severity. Should further cases appear, researchers will assess how dangerous the strain may be and whether it could impact future vaccination strategies.
